1 In vivo cluster formation of nisin and Lipid II is correlated with membrane
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چکیده
In vivo cluster formation of nisin and Lipid II is correlated with membrane 1 depolarization 2 3 Menno B. Tol, Danae Morales Angeles, Dirk-Jan Scheffers 4 5 Department of Molecular Microbiology, Groningen Biomolecular Sciences and 6 Biotechnology Institute, University of Groningen, The Netherlands 7 8 Running Title: Nisin-Lipid II clusters and membrane depolarization 9 10 #Address correspondence to Dirk-Jan Scheffers, [email protected] 11 a M.B.T. and D.M.A. contributed equally to this work. 12 13 keywords: lantibiotics, mechanism-of-action, antimicrobial peptide, Gram-positive 14 bacteria, Bacillus subtilis, peptidoglycan synthesis. 15 AAC Accepted Manuscript Posted Online 13 April 2015 Antimicrob. Agents Chemother. doi:10.1128/AAC.04781-14 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity.
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تاریخ انتشار 2015